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Calcium Beta-hydroxybutyrate

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BHB Ca Salt;

Calcium BHB Salt;

Calcium 3-hydroxybutyrate;

Calcium 3-hydroxybutyrate;

Calcium Beta-hydroxyburyrate;

3-Hydroxybutanoic acid calcium salt;

3-Hydroxybutanoic acid calcium salt (2:1)

Molecular structure:






White powder








Loss on drying




The results conforms with enterprise standards



Calcium Beta-hydroxybutyrate is mainly used as a nutritional supplement for the manufacture of ketone based products.

What is beta-hydroxybutyrate(BHB)?

Beta-hydroxybutyrate (BHB) is also known as beta-hydroxybutyrate or 3-hydroxybutyrate or 3HB. BHB is a ketone body used primarily to provide energy to the brain, heart and muscles. It is one of the three ketones that the liver synthesizes under the protection of the ketones of the human body and is synthesized at low carbohydrates. The other two are acetoacetate and acetone.

Beta-hydroxybutyrate (BHB) is the highest ketone in human blood and usually accounts for about 78% of the ketones in the blood. BHB is the end product of the expected ketogenic action.

Acetoacetate is the second highest ketone in the blood of the human body and usually accounts for about 20% of the ketones in the blood. BHB is produced from acetoacetate, but acetoacetate is not as stable as BHB, so it can be spontaneously converted to acetone before it reacts with BHB.

Acetone is a type of ketone with the least amount of ketone in the blood of the human body, accounting for about 2% of the ketone in the blood.

Both BHB and acetone are derived from acetoacetate, but BHB is a class of ketones that consume energy, while acetone does not consume any energy and is almost directly removed from the body by breathing and sweat.

BHB is considered to be a clean source of fuel because it has a high BHB content in the blood in ketosis (ketosis is a metabolic state in which ketone is used instead of glucose as energy), so it is the main source of energy for the body in the absence of glucose. And it produces less inflammation in the body than glucose.

Carbohydrates are the "preferred fuel source" for the human body and the first type of energy used for body and cellular activities. When there is a lack of carbohydrates, the liver breaks down fatty acids, producing ketone bodies that provide energy to the brain, heart and muscles. In addition, it can help the body to produce ketones, which use fat as a fuel, which means that BHB can not only burn fat, but also provide energy sources for the body, thereby improving the efficiency of weight loss. On the one hand, we can increase the BHB content by eating ketogenic foods. Most of the ketogenic foods are found on our table, such as eggs and milk. On the other hand, BHB can be increased by exogenous supplements.

Ten benefits of beta-hydroxybutyrate(BHB) salt


Prevent or treat diabetes and insulin resistance

BHB salts can lower blood sugar within half an hour after taking and can last for hours. Ketones can control insulin resistance by mimicking certain effects of insulin to control blood sugar and insulin levels. People with lower blood sugar are more sensitive to insulin, so this effect of BHB salt can effectively reduce the incidence of insulin resistance and some of the complications (obesity, type 1 diabetes, metabolic syndrome).

Decreases “Keto Flu” Symptoms

People who take the first ketogenic diet may be affected by the “Keto flu”, including brain fog, irritability, nausea, cravings, stomachaches, and sore muscles. This happens because the body uses glucose as a fuel to fuel fatty acids. It takes a while to change the process. The length and severity of this process varies from person to person, but usually lasts for a week or so. However, because BHB salt can cross the blood-brain barrier, it can greatly alleviate or even eliminate the troubles caused by this process.

Reduce inflammation

We all know that systemic inflammation can cause many chronic diseases, such as heart disease, autoimmune diseases and type 2 diabetes, and BHB can alleviate the inflammation associated with these diseases. Studies have shown that BHB salts can block inflammatory proteins called NLRP3 inflammatory bodies and reduce the release of inflammatory molecules including interleukins IL-1β, IL-18 and TNF-α, helping to treat gout and prevent gout attacks.

Extend your life

Studies have shown that limiting calorie intake can at least extend life by increasing the level of ketone bodies to some extent. The researchers believe that BHB blocks the insulin-like growth factor (IGF-1) receptor gene. This gene promotes cell growth and proliferation, but overgrowth causes many diseases and premature death, while lower IGF-1 activity delays aging and prolongs lifespan. Activation of the FOXO3a gene, which increases the production of antioxidants, also helps to extend lifespan.

Enhance cognitive ability and protect the brain

Although the brain only accounts for 2% of the body's weight, it consumes 20% of the body's energy every day. Usually, the brain relies on glucose as a source of energy. However, during the ketogenic diet, the supply of glucose is insufficient, which can be the main source of energy for the brain, which can provide the brain with about 70 by easily crossing the blood-brain barrier. % of energy demand.

In addition, BHB can act as a neuroprotective antioxidant, prevent and treat epilepsy and neurodegenerative diseases, prevent brain atrophy and plaque buildup, reduce free radicals, reduce neuroinflammation and improve cognitive ability in patients with dementia.

Help to lose weight

We all know that weight loss is achieved through fat burning and diet control. When you control your diet, reduce your carbohydrate intake, and start a ketogenic diet, your body begins to get into ketosis. At this point, your ability to burn fat is greatly enhanced, and some exercise increases the ketone body renewal. Further promote the burning of fat. In addition, you will also experience that appetite suppressing effects of ketones. But don't worry, we already know that in the case of insufficient carbohydrate intake, ketones can burn our body to provide energy for our body. . When we combine the two weight loss effects of BHB, then your weight loss will be twice the result with half the effort.

Helps gene expression

It is vital that the DNA stores the genetic information of our body. If the expression of DNA is restricted or damaged, the protein synthesis capacity of the cell will be impaired, leading to a series of complications that threaten our health and even our lives. However, BHB can improve the accessibility of genes (such as FOXO and MTL1) by inhibiting deacetylase (HDAC), enabling humans to regulate oxidative stress resistance, metabolism, cell cycle and apoptosis more effectively. This has a positive effect on our longevity and vitality.

Prevent and fight cancer

So far, no drug claims to cure cancer completely, but we can prevent and fight cancer, and BHB can achieve this goal. In general, the growth and spread of cancer cells requires energy from glucose to obtain energy from ketones, but healthy cells can. Therefore, in humans with ketosis, despite the lack of energy support for glucose, because ketones provide energy to the human body, cancer cells cannot grow and spread, which has found a new way to prevent and fight cancer. But BHB does not help prevent and fight all cancers.

Enhance athletic performance

To date, there has been a lot of research on how BHB affects athletic performance. These studies have shown that ketones can improve the body's motor performance in low- and medium-intensity aerobic exercise, which helps to indirectly replenish glycogen stores and accelerate the recovery of the body. Early studies have shown that taking a chemical called 3-hydroxybutyl-3-hydroxybutyrate, which is converted to beta-hydroxybutyrate in the body, may help athletes speed up running. Overall, BHB can help reduce fatigue, increase endurance and improve athletic performance.

Fights oxidative stress

Oxidative stress may accelerate aging and cause a variety of chronic diseases. BHB, as a more efficient source of energy than glucose, prevents and reverses oxidative stress in the brain and body. In endothelial cells, ketones activate antioxidants, thereby protecting the cardiovascular system. In areas of the brain that are responsible for advanced functions such as cognition, language, and sensory perception, BHB protects nerve cells from free radicals and oxidation.

How does beta-hydroxybutyrate(BHB) work?

When BHB enters your body, the digestive system breaks it down into free BHB and free metal ions (calcium, magnesium, potassium, sodium), moves through your body through the blood, and then through the blood- The brain barrier, which enters the brain and muscle cells, converts BHB to acetoacetate, converts it to acetyl-CoA, enters the citric acid ring and produces ATP (the molecular unit of the intracellular energy transport currency). At this time, the energy source of our body is supplied by BHB salt.

Is beta-hydroxybutydrate(BHB) safe?

Many studies have shown that BHB salts are trustworthy, and the FDA has identified various forms of BHB as "Generally recognized as safe (GRAS)." Generally, according to the recommendations on the label for exogenous BHB supplements on the market. The dose to eat does not cause any major side effects. But keep in mind that high levels of ketones in the blood can be life-threatening. Therefore, consult your doctor or professional before adding BHB salt to your diet, just like any other supplement.

Side effects of beta-hydroxybutydrate(BHB)

In general, BHB or any ketone does not have any side effects for most people who follow the ketogenic diet correctly. Common side effects include bad breath, physical fatigue, weakness, indigestion, dizziness, hypoglycemia, mood changes, frequent urination, constipation and cramps.  This is what we call ketone flu. But don't worry, this is the performance of the body in adapting to ketosis, only temporary, lasting up to one to two weeks.

What is a ketogenic diet?

The basic principle of the ketogenic diet is to eat high-fat, low-carbohydrate meals, generally 20% protein and 70% fat, and 5% of the total daily demand for carbohydrates. The ketone content in the diet induces ketoacidosis.




Store in a dry, well-ventilated place away from direct sunlight.