info

product name:

Chlorhexidine gluconate

cas No. :

18472-51-0

MF :

C34H54Cl2N10O14

MW :

897.76

Taian, China

9/F,E-commerce Industrial Park

+86 156 6659 0861

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sales@taiangreenindustry.com

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Detail

Quick Details

Synonyms:

Chlorhexidine digluconate;

Chlorhexidine gluconate 20% solution;

Chlorhexidine digluconate 20% solution;

1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

Molecular structure:

Properties

Item

Specifications

Results

Appearance

Colorless to light yellow liquid

Light yellow liquid

Relative density

1.06~1.07

1.064

Identify

①②③ should be positive reaction.

Conforms

pH

5.5~7

5.8

P-chloroaniline

≤25ppm

15ppm

Related substance

Should conform the rule

Conforms

Residue on ignition

≤0.1%

0.01%

Assay

19~21%

20.0%

Conclusion

The results conform with the China Pharmacopeia,Secunda Partes,2015.

 

Quality standard

BP2010 / EP7.0 / CP2010 / USP34

Description

Chlorhexidine gluconate is an effective disinfectant and antiseptic. It has a very strong broad-spectrum bacteriostatic and bactericidal effect, and is effective against Gram-positive bacteria and Gram-negative bacteria. Chlorhexidine gluconate is mainly used for disinfection of external hands and skin, washing wounds.

Recommended dosage

Before operation, skin disinfection or equipment emergency disinfection chlorhexidine gluconate 0.5% solution, prevention of wound infection disinfection chlorhexidine gluconate 0.05% solution, finger and instrument disinfection chlorhexidine gluconate 0.02% solution.

Advantage

Chlorhexidine gluconate has fast and long-lasting effects, very low toxicity, almost not absorbed by the body, and harmless to the human body. Under the effective concentration, it has no stimulating effect and allergic reaction to various tissues.

Precautions

Chlorhexidine gluconate is not compatible with soap and potassium iodide. Cork stoppers should not be used in containers containing chlorhexidine gluconate to avoid inactivation. Chlorhexidine gluconate at a concentration of 0.05% is incompatible with borax, bicarbonate, carbonate, oxide, citrate, phosphate, and sulfate, because it can form a salt with low solubility and precipitate after 24 hours.

Indications

Chlorhexidine digluconate 20% solution can be used for angina and oral ulcers.

Chlorhexidine digluconate ointment can be used for mild small area burns, scalds, and trauma infections, as well as eczema, acne, tinea pedis, etc.

Chlorhexidine digluconate gargle can be used to prevent and treat oral diseases (such as gingivitis, oral ulcers, pharyngitis, etc.).

Pharmacokinetics

Chlorhexidine digluconate 20% solution is positively charged. It is absorbed on the surface of negatively charged teeth, plaque and oral mucosa during oral gargle. The absorbed drug then diffuses from these parts and is gradually released. Partly excreted with feces.

Chlorhexidine gluconate oral rinse

Chlorhexidine gluconate mouthwash currently on the market has a content of 0.12%. It is mainly used to treat oral ulcers, oral infections and other symptoms in people with low immunity.

Chlorhexidine gluconate kill virus

Suspension quantitative sterilization test showed that the disinfection solution composed of chlorhexidine gluconate 2000mg/L and 53% ethanol had an effect on Staphylococcus aureus and Escherichia coli for 0.5min, and the logarithmic kill value was all >500; the effect on Candida albicans is 0.5min, and the logarithmic kill value is >400. Using the disinfectant to rub both hands for 10 minutes, the average log of killing of natural bacteria on the surface of the hands is >2.45, and the log of killing of each test is >100.

Is chlorhexidine gluconate toxic?

The acute oral toxicity test shows that the LD50 of rats and mice are> 5000mg/kg BW, which is actually non-toxic. It has no irritation to rabbit skin. The micronucleus toxicity test showed that there was no significant difference between the test group and the negative control group, and no mutagenic effect was seen; the result of the subacute toxicity test, the dosage is below 1000mg/kg BW, compared with the negative control group , Visceral body coefficient, blood routine and serum biochemical indicators of the rats had no significant effect, and no abnormalities were found in histopathological examination of organs.

Conclusion

Chlorhexidine gluconate compound ethanol disinfectant has low toxicity and little skin irritation. Toxicology is safe at the concentration used.

Packaging

Powder: 20kg/carton

Solution: 5kg/drum or 10kg/drum or 20kg/drum or 25kg/drum or 200kg/drum

Storage

Store in a dry, well-ventilated place away from direct sunlight.

COA,