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Quick Details
Synonyms:
α-Arbutin;
4-Hydroxyphenyl-alpha-D-glucopyranoside;
4-Hydroquinone-alpha-D-glucopyranoside
Molecular structure:
Properties
|
Item |
Specifications |
Results |
|
Appearance |
White crystalline powder |
Conforms |
|
Assay |
≥99% |
99.2% |
|
Hydroquinone |
≤10ppm |
3ppm |
|
pH |
5~7 |
6 |
|
Optical Rotation |
+175°~+185° |
Conforms |
|
Heavy metals |
≤10ppm |
4ppm |
|
Loss on drying |
≤0.5% |
0.18% |
|
Moisture |
≤0.5% |
0.24% |
|
Conclusion |
The results conforms with enterprise standards |
|
Description
α-Arbutin is an isomer of β-arbutin and is mainly used as a whitening agent in cosmetics. Its whitening effect is similar to that of β-arbutin, which reduces the production and deposition of melanin by inhibiting the activity of tyrosinase, and eliminates pigmentation and freckles. Studies have shown that α-arbutin can inhibit tyrosinase activity at relatively low concentrations. It has a better inhibitory effect on tyrosinase than β-arbutin, but the price is slightly higher.
α-Arbutin VS β-Arbutin
Production Process
β-arbutin can be prepared by three methods of plant extraction, plant cell culture and chemical synthesis, while α-arbutin can only be prepared by enzyme synthesis method (microbial fermentation method).
Whitening effect
The tyrosinase inhibition test and B16 melanoma cell test show that α-arbutin can more effectively inhibit tyrosinase, thereby effectively inhibiting melanin expression in B16 cells, and its whitening effect is that of β-arbutin 10 times as much.
Safety
Studies have shown that at the same concentration, α-arbutin can effectively inhibit melanin without inhibiting the growth of melanocytes, but β-arbutin significantly inhibits or damages the growth of melanocytes, resulting in cytotoxicity. The toxicological effects of β-arbutin cannot be ignored. If the growth of melanocytes is disrupted or inhibited, it can cause diseases such as the genetic disease albino and a malignant tumor called melanoma. It can be seen that α-arbutin has higher safety than β-arbutin.
Stability
From a temperature perspective, the α-arbutin solution remained stable at about 100℃, and no hydroquinone was detected, but the β-arbutin solution was decomposed to produce hydroquinone at temperatures above 50℃.
From the perspective of acid-base conditions, the α-arbutin solution can maintain stability in the pH range of 5.2-8, and no hydroquinone is detected, but it is found that the β-arbutin solution contains a small amount of hydroquinone.
Therefore, it can be seen that α-arbutin is more stable than β-arbutin.
Packaging
25kg/drum
Storage
Store in a dry, well-ventilated place away from direct sunlight.
COA,