info

product name:

alpha-Arbutin

cas No. :

84380-01-8

MF :

C12H16O7

MW :

272.25

Taian, China

9/F,E-commerce Industrial Park

+86 156 6659 0861

Mon to Fri 8am to 6 pm

sales@taiangreenindustry.com

Send us your inquiry anytime!

Detail

Quick Details

Synonyms:

α-Arbutin;

4-Hydroxyphenyl-alpha-D-glucopyranoside;

4-Hydroquinone-alpha-D-glucopyranoside

Molecular structure:

 

Properties

Item

Specifications

Results

Appearance

White crystalline powder

Conforms

Assay

≥99%

99.2%

Hydroquinone

≤10ppm

3ppm

pH

5~7

6

Optical Rotation

+175°~+185°

Conforms

Heavy metals

≤10ppm

4ppm

Loss on drying

≤0.5%

0.18%

Moisture

≤0.5%

0.24%

Conclusion

The results conforms with enterprise standards

 

Description

α-Arbutin is an isomer of β-arbutin and is mainly used as a whitening agent in cosmetics. Its whitening effect is similar to that of β-arbutin, which reduces the production and deposition of melanin by inhibiting the activity of tyrosinase, and eliminates pigmentation and freckles. Studies have shown that α-arbutin can inhibit tyrosinase activity at relatively low concentrations. It has a better inhibitory effect on tyrosinase than β-arbutin, but the price is slightly higher.

α-Arbutin VS β-Arbutin

Production Process

β-arbutin can be prepared by three methods of plant extraction, plant cell culture and chemical synthesis, while α-arbutin can only be prepared by enzyme synthesis method (microbial fermentation method).

Whitening effect

The tyrosinase inhibition test and B16 melanoma cell test show that α-arbutin can more effectively inhibit tyrosinase, thereby effectively inhibiting melanin expression in B16 cells, and its whitening effect is that of β-arbutin 10 times as much.

Safety

Studies have shown that at the same concentration, α-arbutin can effectively inhibit melanin without inhibiting the growth of melanocytes, but β-arbutin significantly inhibits or damages the growth of melanocytes, resulting in cytotoxicity. The toxicological effects of β-arbutin cannot be ignored. If the growth of melanocytes is disrupted or inhibited, it can cause diseases such as the genetic disease albino and a malignant tumor called melanoma. It can be seen that α-arbutin has higher safety than β-arbutin.

Stability

From a temperature perspective, the α-arbutin solution remained stable at about 100℃, and no hydroquinone was detected, but the β-arbutin solution was decomposed to produce hydroquinone at temperatures above 50℃.

From the perspective of acid-base conditions, the α-arbutin solution can maintain stability in the pH range of 5.2-8, and no hydroquinone is detected, but it is found that the β-arbutin solution contains a small amount of hydroquinone.

Therefore, it can be seen that α-arbutin is more stable than β-arbutin.

Packaging

25kg/drum

Storage

Store in a dry, well-ventilated place away from direct sunlight.

COA,